Type 2 Diabetes Medications

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Metformin gluconeogen Lactic acidosis
Sulfonylureas(chlorpropamide, glyburide, glipizide) Close K channels insulin release Weight gain, hypoglycemia
TZD (Rosiglitazone) Bind to PPARy insulin sensitivity Weight gain
Edema, CHF, Bladder cancer, bone fracts.
Can be used in renal insuf.
Insulin (add if HBA1c>8.5%)
Rapid: Lispro, aspart, glulisine
Short: Regular
Intermediate: NPH
Long: glargine, detemir
Hypoglycemia
Weight gain
DPP-IV inhibitors (sitagliptin) GLP-1
GLP-1 analogs (exenatide, liraglutide) glucose dependent insulin secretion Pancreatitis
Weight loss