Paget’s disease of the bone (osteitis deformans)

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osteoclastic bone resorption abnormal focal bone remodeling (mosaic)

Presentation

  • Asymptomatic
  • Hearing loss, dizziness
  • head size
  • Bone pain, spinal stenosis
  • Bowing deformities of long bones

Complications

  • Osteosarcoma
  • Fractures
  • Hearing loss

Diagnosis

  • X-ray (osteolytic or mixed lesions) and ALP
  • Bone scan is more sensitive and documents extent and location
  • Ca and P are usually normal

Treatment

Bisphosphonates