Nephrotic syndrome

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Focal segmental
glomerulosclerosis
Blacks and Hispanics
HIV
Heroin, Obesity, SCD
Segmental sclerosis and hyalinosis
IF -
EM: Effacement of foot processes
Minimal change disease Children
Hodgkin lymphoma
NSAIDS
Normal glomeruli
IF -
EM: Effacement of foot processes
Membranous SLE
HBV and HCV
PLA2r antibody
NSAIDs
Solid tumors
Diffuse capillary and GBM thickening
IF: granular (immune complex deposition)
EM: spike and dome, subepithelial deposits
MPGN Type 1: HBV and HCV

Type 2: C3 nephritic factor
Type 1:
  • Subendothelial immune complex deposition
  • IF: granular
  • Tram track due to mesangial growth and GBM splitting

Type 2:

  • Intramembranous dense deposits