Leukocyte adhesion deficiency

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  • CD18 deficiency
  • Presentation:
    • Absence of pus formation
    • Delayed umbilical cord separation
    • Poor wound healing
    • Recurrent skin and mucosal infections
    • Necrotizing periodontitis
  • Diagnosis:
    • Leukocytosis with neutrophilia
    • Biopsy of infected tissue shows inflammatory infiltrate without neutrophils