Hepatitis B

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Treatment

Indications:

  • Acute liver failure
  • Clinical complications of cirrhosis
  • Advanced cirrhosis with ↑ HBV DNA
  • +HBeAg, HBV DNA>20,000 and ALT>2x upper limit of normal
  • Prevent HBV reactivation during chemotherapy or immunosuppression

Options:

  • IFN: young patients with compensated liver disease, short-term
  • Lamivudine: maybe in HIV
  • Entecavir: Decompensated cirrhosis
  • Tenofovir: preferred